North
Seattle Community College Winter
2009
Chemistry 256: Biochemistry II
Meeting
times and rooms: MW, 6:00 – 7:20 p.m., AS 1520
Text: Fundamentals of
Biochemistry by Voet, Voet and Pratt, 3rd edition
Other
materials: A
scientific calculator and an organic chemistry text
Purpose: This
course is the second of a two-quarter series and is a survey of basic
principles of biochemistry and molecular biology, emphasizing broad
understanding of chemical events in living systems in terms of metabolism and
structure-function relationships of biologically important molecules. Suitable
for pre-majors, for students interested in careers in medicine, dentistry,
pharmacy, medical technology. There is no lab component to this class. In this
quarter, we will emphasize the nature of lipids and nucleic acids in biological
systems.
Prerequisites: CHEM 255
Instructor: Tracy
Furutani Office:
IB 2328B
Phone: 528-4509 Office
hour: M 4 – 6 p.m.
e-mail: tfurutan@northseattle.edu
website: http://faculty.northseattle.edu/tfurutani/
Grading: Exams
2 at 100 pts, better one 100
Case studies 5 at
20 pts each 100
Exercises 6 at 10 pts each, best
5 50
Term project 50
Total 300
pts
There is no final for the class; the poster presentation will
be held during the time allotted for the final and you will be expected to
attend.
Grades will be assigned as follows:
Your total points: 285
– 300 Your grade: 4.0
270 – 284 3.7
255 – 269 3.3
240 – 254 3.0
225 – 239 2.7
210 – 224 2.3
195 – 209 2.0
180 – 194 1.7
165 – 179 1.3
150 – 164 1.0
< 150
0.0
Course Learning Goals: Upon
successfully completing this course the student should:
1. have
a working vocabulary (can give a definition, use terms in context, apply the
term to a new context) of biochemical terms.
2. be
able to identify/explain the biochemical structure of proteins, carbohydrates,
and lipids.
3. be
able to list and explain the various functions of proteins, carbohydrates, and
lipids.
4. be
able to predict/explain the behavior of biomolecules/biochemical systems by
applying chemical principles to these systems.
5. be
able to explain and interpret data generated from application of biochemical techniques.
6. be
able to transform written descriptions of quantitative behaviors of
biomolecules into graphical representations and vice versa.
7. be
able to understand, interpret, and formulate models that represent the current
understanding of a macromolecule or biological system.
8. be
able to interpret experimental data and relate the interpretation to the
current knowledge of biological systems.
9. be
able to use a methodology to read and interpret a scientific research article
and be able to articulate its contents.
10. be
able to use a problem-solving methodology to solve problems involving
biomolecules and utilizing biochemical techniques.
be able to work cooperatively in teams
to identify a problem, formulate a plan, and accomplish a task.
Exams: These are
in-class, open-book and notes. The midterms will be 80 minutes long.
Homework: These are
end-of-the-chapter problems that have reasonably full answers in the appendix.
Hence, they are not to be turned in for credit, but will give an indication of
the kinds of questions to be asked on an exam. Note the chapters are in the
order presented in class.
Chapter 19: #2, 4, 5, 8, 10, 13
Chapter 16: #1, 4, 5, 9
Chapter 9: #3, 4, 5, 6, 8, 11
Chapter 20: #1, 3, 4, 7, 8, 12
Chapter 21: #2, 3, 5, 7, 11, 12
Chapter 3: #1, 3, 5, 9, 10, 14, 16
Chapter 23: #1, 4, 5, 6, 7, 11
Chapter 24: #2 (see Ch. 25, question 3), 5, 7, 9, 10, 16
Chapter 25: #2, 3, 4, 6, 11, 13, 15
Chapter 26: #1, 2, 4, 6, 13
Chapter 27: #2, 4, 5, 9, 11, 16
Case
studies:
These are out-of-class activities I expect you to complete in small groups.
They are found at the Wiley textbook site at http://wiley.com/college/voet and
clicking the appropriate student instruction links. Each case study has a data
set from which you are to analyze and infer the answers to questions at the end
of the study. Not all questions are required to be answered, so check the
calendar to see which questions to do.
Exercises: These are
in-class written assignments that should be worked on in groups. The exercise
material emphasizes course information. The exercises are due after we go over
them in class.
Term project: There will be a handout on this
assignment.
Attendance: Since we
meet as a group only 20 times this quarter, it is imperative that you attend
all class meetings. Exercises, for instance, can be done only during the class
time. Please notify me if you cannot attend a meeting.
Class
schedule (provisional – exam dates may change)
|
January 5 Photosynthesis – dark rxns Read VV&P, pp. 663-675 (section 19-3) |
6 |
7 Pentose phosphate pathway Read VV&P, pp. 520-527 (section 15-6) Glycogen metabolism Read VV&P, pp. 530-544 (sections 16-1 and 16-2) |
8 |
9 |
|
12 Gluconeogenesis Read VV&P, pp. 545-560 (sections 16-3 and 16-4) |
13 |
14 Lipids Read VV&P, pp. 245-272 (sections 9-1 through 9-4A) Case
study 21 due (Questions 4-8) |
15 |
16 |
|
19 Martin
Luther King, Jr. Day |
20 |
21 Fatty acid oxidation Read VV&P, pp. 677-698 (sections 20-1 and 20-2) |
22 |
23 |
|
26 Fatty acid oxidation Read VV&P, pp. 698-729 (sections 20-3 through 20-7) |
27 |
28 Case
study 25 due (Questions
1-5) |
29 |
30 |
|
February 2 Amino acid catabolism Read VV&P, pp. 732-762 (sections 21-1 through 21-4) |
3 |
4 Amino acid biosynthesis Read VV&P, pp. 763-782 (sections 21-5 and 21-6) |
5 |
6 |
|
9 Introduction to nucleic acids Read VV&P, chapter 3 |
10 |
11 Nucleotide biosynthesis Read VV&P, Chapter 23 Case
study 3 due (Questions
1-4) |
12 |
13 |
|
16 Presidents
Day |
17 |
18 Exam
1
(first nine lectures) |
19 |
20 |
|
23 Nucleic acid characterization Read VV&P, pp. 848-874 (sections 24-1 through 24-3) |
24 |
25 Eukaryotic chromosomes Read VV&P, pp. 874-890 (sections 24-4 and 24-5) Case
study 30 due (Questions
1,3,5,6,7,11) |
26 |
27 |
|
March 2 DNA replication Read VV&P, pp. 893-916 (sections 25-1 through 25-3) |
3 |
4 DNA damage and repair Read VV&P, pp. 916-939 (sections 25-4 through 25-6) |
5 |
6 |
|
9 Transcription Read VV&P, pp. 942-965 (sections 25-1 and 25-2) |
10 |
11 RNA processing Read VV&P, pp. 965-982 (section 26-3) Case
study 31 due (Questions
1-6) |
12 |
13 |
|
16 Transfer RNA and translation Read VV&P, chapter 27 Exam 2 (last
nine lectures) Project talks |
17 |
18 Poster presentations |
19 |
20 |