North Seattle Community College                                      Winter 2009

 

Chemistry 256: Biochemistry II

Meeting times and rooms: MW, 6:00 – 7:20 p.m., AS 1520

 

Text: Fundamentals of Biochemistry by Voet, Voet and Pratt, 3rd edition

Other materials:      A scientific calculator and an organic chemistry text

 

Purpose: This course is the second of a two-quarter series and is a survey of basic principles of biochemistry and molecular biology, emphasizing broad understanding of chemical events in living systems in terms of metabolism and structure-function relationships of biologically important molecules. Suitable for pre-majors, for students interested in careers in medicine, dentistry, pharmacy, medical technology. There is no lab component to this class. In this quarter, we will emphasize the nature of lipids and nucleic acids in biological systems.

 

Prerequisites: CHEM 255

 

Instructor: Tracy Furutani                                    Office: IB 2328B

Phone: 528-4509                                         Office hour: M 4 – 6 p.m.

e-mail: tfurutan@northseattle.edu

website: http://faculty.northseattle.edu/tfurutani/

   

Grading:              Exams                  2 at 100 pts, better one               100

                                    Case studies     5 at 20 pts each                        100

                           Exercises     6 at 10 pts each, best 5                50

                                    Term project                                                  50

 

                                    Total                                                           300 pts

 

There is no final for the class; the poster presentation will be held during the time allotted for the final and you will be expected to attend.

 

Grades will be assigned as follows:

Your total points:    285 – 300 Your grade:       4.0

                                    270 – 284                          3.7

                                    255 – 269                          3.3

                                    240 – 254                          3.0

                                    225 – 239                          2.7

                                    210 – 224                          2.3

                                    195 – 209                          2.0

                                    180 – 194                          1.7

                                    165 – 179                          1.3

                                    150 – 164                          1.0

                                    < 150                                0.0

 

Course Learning Goals: Upon successfully completing this course the student should:

1.    have a working vocabulary (can give a definition, use terms in context, apply the term to a new context) of biochemical terms.

2.    be able to identify/explain the biochemical structure of proteins, carbohydrates, and lipids.

3.    be able to list and explain the various functions of proteins, carbohydrates, and lipids.

4.    be able to predict/explain the behavior of biomolecules/biochemical systems by applying chemical principles to these systems.

5.    be able to explain and interpret data generated from application of  biochemical techniques.

6.    be able to transform written descriptions of quantitative behaviors of biomolecules into graphical representations and vice versa.

7.    be able to understand, interpret, and formulate models that represent the current understanding of a macromolecule or biological system.

8.    be able to interpret experimental data and relate the interpretation to the current knowledge of biological systems.

9.    be able to use a methodology to read and interpret a scientific research article and be able to articulate its contents.

10.  be able to use a problem-solving methodology to solve problems involving biomolecules and utilizing biochemical techniques.

be able to work cooperatively in teams to identify a problem, formulate a plan, and accomplish a task.

 

Exams: These are in-class, open-book and notes. The midterms will be 80 minutes long.

 

Homework: These are end-of-the-chapter problems that have reasonably full answers in the appendix. Hence, they are not to be turned in for credit, but will give an indication of the kinds of questions to be asked on an exam. Note the chapters are in the order presented in class.

 

Chapter 19: #2, 4, 5, 8, 10, 13

Chapter 16: #1, 4, 5, 9

Chapter 9: #3, 4, 5, 6, 8, 11

Chapter 20: #1, 3, 4, 7, 8, 12

Chapter 21: #2, 3, 5, 7, 11, 12

Chapter 3: #1, 3, 5, 9, 10, 14, 16

Chapter 23: #1, 4, 5, 6, 7, 11

Chapter 24: #2 (see Ch. 25, question 3), 5, 7, 9, 10, 16

Chapter 25: #2, 3, 4, 6, 11, 13, 15

Chapter 26: #1, 2, 4, 6, 13

Chapter 27: #2, 4, 5, 9, 11, 16

 

Case studies: These are out-of-class activities I expect you to complete in small groups. They are found at the Wiley textbook site at http://wiley.com/college/voet and clicking the appropriate student instruction links. Each case study has a data set from which you are to analyze and infer the answers to questions at the end of the study. Not all questions are required to be answered, so check the calendar to see which questions to do.

 

Exercises: These are in-class written assignments that should be worked on in groups. The exercise material emphasizes course information. The exercises are due after we go over them in class.

 

Term project: There will be a handout on this assignment.

 

Attendance: Since we meet as a group only 20 times this quarter, it is imperative that you attend all class meetings. Exercises, for instance, can be done only during the class time. Please notify me if you cannot attend a meeting.

 

 Class schedule (provisional – exam dates may change)

 

January 5

Photosynthesis – dark rxns

Read VV&P, pp. 663-675 (section 19-3)

6

7 Pentose phosphate pathway

Read VV&P, pp. 520-527 (section 15-6)

Glycogen metabolism

Read VV&P, pp. 530-544 (sections 16-1 and 16-2)

 

Exercise 1

8

9

12

Gluconeogenesis

Read VV&P, pp. 545-560

(sections 16-3 and 16-4)

13

14 Lipids

Read VV&P, pp. 245-272 (sections 9-1 through 9-4A)

Case study 21 due (Questions 4-8)

 

Term project

15

16

19

Martin Luther King, Jr. Day

 

20

21

Exercise 2

Fatty acid oxidation

Read VV&P, pp. 677-698 (sections 20-1 and 20-2)

22

23

26

Fatty acid oxidation

Read VV&P, pp. 698-729

(sections 20-3 through 20-7)

27

28

Case study 25 due

(Questions 1-5)

 

Exercise 3

29

30

February 2

Amino acid catabolism

Read VV&P, pp. 732-762

(sections 21-1 through 21-4)

3

4

Amino acid biosynthesis

Read VV&P, pp. 763-782 (sections 21-5 and 21-6)

5

6

9

Introduction to nucleic acids

Read VV&P, chapter 3

10

11 Nucleotide biosynthesis

Read VV&P, Chapter 23

Case study 3 due

(Questions 1-4)

12

13

16

Presidents Day

17

18

Exercise 4

Exam 1 (first nine lectures)

19

20

23

Nucleic acid characterization

Read VV&P, pp. 848-874

(sections 24-1 through 24-3)

24

25 Eukaryotic chromosomes

Read VV&P, pp. 874-890 (sections 24-4 and 24-5)

Case study 30 due

(Questions 1,3,5,6,7,11)

26

27

March 2

DNA replication

Read VV&P, pp. 893-916

(sections 25-1 through 25-3)

 

Exercise 5

3

4

DNA damage and repair

Read VV&P, pp. 916-939 (sections 25-4 through 25-6)

5

6

9

Transcription

Read VV&P, pp. 942-965

(sections 25-1 and 25-2)

10

11 RNA processing

Read VV&P, pp. 965-982 (section 26-3)

Case study 31 due

(Questions 1-6)

12

 

13

 

16 Transfer RNA and translation

Read VV&P, chapter 27

 

Exam 2 (last nine lectures)

 

Project talks

17

18

Poster presentations

19

20