North Seattle Community College                                                           Fall 2008

 

Chemistry 255: Introduction to Biochemistry

 

Meeting times and rooms: MW, 6:00 – 7:20 p.m., AS 1614

 

Text: Fundamentals of Biochemistry by Voet, Voet and Pratt, 3rd edition

 

Other materials:       A scientific calculator and an organic chemistry text

 

Purpose: This course is the first of a two-quarter series and is a survey of basic principles of biochemistry and molecular biology, emphasizing broad understanding of chemical events in living systems in terms of metabolism and structure-function relationships of biologically important molecules. Suitable for pre-majors, for students interested in careers in medicine, dentistry, pharmacy, medical technology. There is no lab component to this class.

 

Prerequisites: CHEM& 243 (formerly CHE 236) with a 2.0 or better, BIOL& 211 (formerly BIO 201) or BIOL& 160 (formerly BIO 101) with a 2.0 or better

 

Instructor: Tracy Furutani                                      Office: IB 2328B

Phone: 528-4509                                                       Office hour: by appointment

e-mail: tfurutan@northseattle.edu

website: http://faculty.northseattle.edu/tfurutani/

 

I will post most of the handouts from class on the course website in pdf form.

  

Grading:                    Exams                        2 at 100 pts, better one                   100

                                    Case studies  5 at 20 pts each                                100

                                    Exercises        6 at 10 pts each, best 5                     50

                                    Poster project                                                           50

 

                                    Total                                                                           300 pts

 

There is no final for the class; the poster presentation will be held during the time allotted for the final and you will be expected to attend.

 

Grades will be assigned as follows:

Your total points:     285 – 300 Your grade:          4.0

                                    270 – 284                                3.7

                                    255 – 269                                3.3

                                    240 – 254                                3.0

                                    225 – 239                                2.7

                                    210 – 224                                2.3

                                    195 – 209                                2.0

                                    180 – 194                                1.7

                                    165 – 179                                1.3

                                    150 – 164                                1.0

                                    < 150                                       0.0

Course Learning Goals: Upon successfully completing this course the student should:

1.     have a working vocabulary (can give a definition, use terms in context, apply the term to a new context) of biochemical terms.

2.     be able to identify/explain the biochemical structure of proteins, carbohydrates, and lipids.

3.     be able to list and explain the various functions of proteins, carbohydrates, and lipids.

4.     be able to predict/explain the behavior of biomolecules/biochemical systems by applying chemical principles to these systems.

5.     be able to explain and interpret data generated from application of  biochemical techniques.

6.     be able to transform written descriptions of quantitative behaviors of biomolecules into graphical representations and vice versa.

7.     be able to understand, interpret, and formulate models that represent the current understanding of a macromolecule or biological system.

8.     be able to interpret experimental data and relate the interpretation to the current knowledge of biological systems.

9.     be able to use a methodology to read and interpret a scientific research article and be able to articulate its contents.

10.  be able to use a problem-solving methodology to solve problems involving biomolecules and utilizing biochemical techniques.

be able to work cooperatively in teams to identify a problem, formulate a plan, and accomplish a task.

 

Exams: These are in-class, closed-book and notes. The midterms will be 80 minutes long.

 

Homework: These are end-of-the-chapter problems that have reasonably full answers in the appendix. Hence, they are not to be turned in for credit, but will give an indication of the kinds of questions to be asked on an exam. Note the chapters are in the order presented in class.

 

Chapter 1: #1, 3, 6, 10, 14

Chapter 2: #2, 3, 6, 11, 12, 17

Chapter 4: #2, 4, 10, 15, 17

Chapter 5: #1, 3, 6, 12, 18, 20

Chapter 6: #3, 6, 16, 17, 19

Chapter 7: #1, 3, 8, 15

Chapter 11: #2, 5, 7, 12, 14, 21

Chapter 12: #4, 6, 8, 10, 18, 23

Chapter 13: #1, 3, 5, 10

Chapter 8: #2, 4, 6, 8, 16

Chapter 14: #1, 4, 5, 8, 10

Chapter 15: #1, 3, 4, 8

Chapter 17: #2, 3, 5, 8

Chapter 18: #2, 4, 7

Chapter 19: #2, 4, 5, 8, 10, 13

Chapter 16: #1, 4, 5, 9

 

Case studies: These are out-of-class activities I expect you to complete in small groups. They are found at the Wiley textbook site at http://wiley.com/college/voet and clicking the appropriate student instruction links. Each case study has a data set from which you are to analyze and infer the answers to questions at the end of the study. Not all questions are required to be answered, so check the calendar to see which questions to do.

 

Exercises: These are in-class written assignments that should be worked on in groups. The exercise material emphasizes course information. The exercises are due after we go over them in class.

 

Poster project: You will choose a topic from a list of pharmaceutical papers. Your project is to generate a poster presentation of the relevant chemistry in that paper. There will be a handout on this assignment, including the list of papers. The presentation will be in class on Monday, December 8.

 

Attendance: Since we meet as a group only 22 times this quarter, it is imperative that you attend all class meetings. Exercises, for instance, can be done only during the class time. Please notify me if you cannot attend a meeting.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 Class schedule (provisional – exam dates may change)

 

September 22

Introduction

Skim VV&P, chapters 1 & 2

 

Exercise 1

23

24

Introduction

Skim VV&P, chapters 1 & 2

25

26

29

Amino acids

Read VV&P, chapter 4

 

Exercise 2

30

October 1

1 protein structures

Read VV&P, pp. 91-153

Case study 1 due (Questions 1-5)

2

3

6

1 protein structures

Read VV&P, pp. 91-153

7

8

2, 3 protein structures

Read VV&P, pp. 91-153

9

10

13

2, 3 protein structures

Read VV&P, pp. 91-153

 

Extra credit key

14

15 Myoglobin and hemoglobin

Read VV&P, pp. 154-197

 

Exercise 3

16

17

20 Myoglobin and hemoglobin

Read VV&P, pp. 154-197

 

Case study 8 due

(Questions 1-5)

21

22

Enzyme kinetics, inhibition

Read VV&P, chapter 11

Read VV&P, pp. 363-385

 

23

24

27

Enzyme kinetics, inhibition

Read VV&P, chapter 11

Read VV&P, pp. 363-385

 

28

29

Enzyme control

Read VV&P, pp. 386-401

 

 

30

31

November 3

 

Enzyme control

Read VV&P, pp. 386-401

 

Exam 1 (proteins)

4

5

Carbohydrates

Read VV&P, chapter 8

 

 

Exercise 4

6

7

10

Carbohydrates

Read VV&P, chapter 8

 

Case study 13 due

(Questions 1-5)

11

12

Introduction to metabolism, and glycolysis

Read VV&P, pp. 448-474 and 485-509

 

13

14

17

Introduction to metabolism, and glycolysis

Read VV&P, pp. 448-474 and 485-509

 

 

18

19

Introduction to metabolism, and glycolysis

Read VV&P, pp. 448-474 and 485-509

 

Exercise 5

Case study 20 due

(Questions 2-6)

20

21

24

Citric acid cycle

Read VV&P, pp. 510-515 and 566-583

 

 

25

26

Electron transport and oxidative phosphorylation

Read VV&P, pp. 596-630

 

Photosynthesis

Read VV&P, pp. 640-663

 

Case study 23 due

(Questions 1-5)

27

Thx

28

gvng

December 1

 

Building carbohydrates

Read VV&P, pp. 663-675 and 520-527

 

Poster abstract due

2

3

Glycogen metabolism and

gluconeogenesis

Read VV&P, pp. 530-560

 

Exam 2 (previous nine lectures)

4

5

8

Poster presentation

 

9

10

11

12