North Seattle Community College Spring 2005

Chemistry 103: Introduction to Biochemistry

Course meeting times: MWTh, 10:00 – 11:50 a.m. (AS 1520)

T, 10:00 – 10:50 a.m. (AS 1520)

Lab days will typically begin in AS 1520 with an introductory lecture; we will then move to AS 1515 to perform the experiments.

Text: General, Organic and Biological Chemistry by Timberlake, Platinum edition

Other required materials:

• Goggles

• Scientific calculator

• Lab notebook (sewn binding, not stapled or glued)

• Lab coat or apron (optional)

Purpose: This course is the final quarter of a three-quarter introductory chemistry sequence. After a brief review of functional groups on organic molecules and oxidation/reduction re-actions, we will cover the major biologically interesting classes of molecules: carbohydrates, proteins, lipids and nucleic acids, both in terms of structure and function. We will finish the course with metabolic pathways — specifically, how the body “converts” carbohydrates, lipids and proteins to energy, and how the body generates biomolecules by scavenging other “used” biomolecules. These topics are contained in Chapters 16, 18, and 20-25 of the book.

Prerequisites: Math 098 (or equivalent) and Chemistry 102 (or equivalent) are prerequisites for this course; these prerequisites are critical for your success in this class. Due to the complexity of the reading, English 101 is strongly recommended.

Instructor: Tracy Furutani Office: IB 2328B

Phone: 528-4509 Office hour: MWTh, noon – 12:50; T, 11 – 11:50

e-mail: tfurutani@sccd.ctc.edu

website: http://faculty.northseattle.edu/tfurutani/

Grades will be posted on the WebCT site; click for instructions on how to access them.

Grading: Labs: 9 at 20 points each 180

Exercises: 11 at 10 points each, best 10 100

Report (oral and written) on Student Activity Center Health News 40

Midterm exams: 3 at 50 points each, best 2 100

Homework: 9 at 10 points each, best 8 80

Final (comprehensive – June 17, 10:30 a.m.) 100

Total 600 points Grades will be assigned as follows:

Your total points: 570 - 600 Your grade: 4.0

540 - 569 3.7

510 - 539 3.3

480 - 509 3.0

450 - 479 2.7

420 - 449 2.3

390 - 419 2.0

360 - 389 1.7

330 - 359 1.3

300 - 329 1.0

< 300 0.0

Homework problems: Note that all odd numbered problems’ answers are in the back of the book; you are responsible for checking these answers. The grader will check more carefully the even-numbered problems; be clear in how you derived the answers! Please use only one side of the sheet of paper and box your final answers; neatly staple answer sheets together. Homework problems for the chapter are due on the same day as the midterm for that chapter. Though I encourage collaboration between students (especially study groups) to work together on these problems, I ask that each person turn in their own set of homework answers.

Unless otherwise specified, if a problem has multiple parts, do all of them.

Organic Chemistry Review (Chapters 11-15, 17, 19): 11.15, 11.26, 11.29, 12.3, 12.6, 12.13, 13.11, 13.22, 13.33, 13.39, 14.8, 14.33, 14.57, 15.21, 15.26, 17.5, 17.25, 17.58, 19.4, 19.7, 19.29

Chapter 16: 16.5, 16.9, 16.13, 16.14, 16.15, 16.19, 16.28, 16.29, 16.32, 16.35, 16.37, 16.49, 16.50, 16.52, 16.57

Chapter 18: 18.4, 18.7, 18.10, 18.15, 18.20, 18.27, 18.31, 18.34, 18.37, 18.42, 18.59, 18.67, 18.69, 18.73, 18.83

Chapter 20: 20.7, 20.12, 20.13, 20.16, 20.17, 20.19 b, 20.27, 20.31, 20.33, 20.34, 20.39, 20.41, 20.44, 20.51, 20.52

Chapter 21: 21.7, 21.13, 21.14, 21.17, 21.20, 21.21, 21.24, 21.25, 21.33, 21.35, 21.43, 21.65, 21.69, 21.70, 21.72

Chapter 22: 22.13, 22.18, 22.29, 22.41, 22.47, 22.52, 22.57, 22.60, 22.61, 22.68, 22.76, 22.93, 22.99, 22.108, 22.109

Chapter 23: 23.6, 23.7, 23.9, 23.13, 23.19, 23.28, 23.31, 23.37, 23.44, 23.45, 23.47, 23.57, 23.79, 23.88, 23.101

Chapter 24: 24.5, 24.10, 24.11, 24.12, 24.15, 24.23, 24.29, 24.34, 24.36, 24.45, 24.47, 24.51, 24.77, 24.84, 24.90

Chapter 25: 25.3, 25.12, 25.13, 25.15, 25.17, 25.21, 25.24, 25.31, 25.36, 25.39, 25.43, 25.52, 25.55, 25.68, 25.71

Exercises: These are in-class hands-on activities that support the lecture material. Exercises may be done in groups; turn in your own exercise sheet for grading.

Labs: Safety first! You must wear goggles in lab; these can be purchased at the Bookstore, though if you have some that are comfortable, bring them and we will determine suitability for lab.

Laboratory Notebooks and Reports: Write in ink (no exceptions) into a bound laboratory notebook. Do not use whiteout; just cross out any unacceptable entries with a single line. Number the pages and use the first two pages for a table of contents. The following items must be included in your lab notebook:

1. Table of contents (first couple of pages)

2. Title of experiment (must include more than the experiment number)

3. Date of experiment

4 Two or three sentences of the purpose, which must be completed before coming to lab.

5. A step-by-step procedure, to the best of your ability before lab. Double-space this section so that you can add changes to the procedure you make during lab.

6. All data and notes taken while performing the experiment.

7. Instead of a formal conclusion, there will be questions that will guide you to the “take home” lesson of the lab. This is the only section of the report that may be word-processed and pasted into your lab notebook later.

Items 1-5 must be completed before coming to lab. The instructor reserves the right to administer a pre-lab quiz (worth a few points of the lab grade) if the perception exists that students are not preparing lab notebooks.

Lab notebooks will be graded throughout the quarter in this way: the lab report will be the photocopied (or other facsimile reproduction) pages pertaining to the experiment in your notebook. Note that rewritten or transcribed pages will not be accepted; this is to encourage you to be legible the first time around. It will be graded for completeness and legibility. Recall that the purpose of a lab notebook is to document what you have done in lab. This means that someone else with a chemistry background should be able to recreate your results just using your lab notebook.

Lab reports (the photocopied pages) will be due at 5 p.m. the Monday after the period in which the experimental work is finished. The instructor reserves the right to impose a 50% penalty on late work.

Even though you will complete some of the experimental work in pairs (and we will begin emphasizing working on your own this quarter), all lab notebooks must be written up individually. Although you may discuss the lab with other students, the report must be written in your own words. If there is evidence of copying for any part of the lab, all students involved will receive a grade of zero on the lab report, and a referral will be made to the Dean. Plagiarism and cheating are quite serious offenses in academia.

Report on Student Activity Center Health News: You (and maybe one partner) will read one of the Health News blurbs that Chris Mogadam at the Student Activities Center (i.e., “gym”) sends out by e-mail. They are short, and give little of the science behind the health tips. You will write two-to-three page (word-processed, double-spaced, cited, proofread) report describing the science behind the tip (in rare instances, some students have found errors in the health tip itself!). You will also present a 10-minute talk, summarizing your findings. Stay tuned for a more in-depth handout.

Exams: The midterm exams are fifty minutes long and cover the material since the last exam; the final is two hours long and is comprehensive. These items represent individual learning, so no collaboration or use of the textbook is allowed. However, since they represent learning (and not memorization), they will be (unless otherwise specified) open notes, handouts, lab notebook, exercises and calculator.

Make-ups: Missed exams and labs cannot be made up; in return, I drop the lowest exam, exercise and homework score.

Cheating: Don't. I will use the policy outlined in the Student Conduct section of the Student Handbook. Remember, a group project is the result of a roughly equal sharing of ideas from each member of the group. Collaboration is absolutely essential. A lab report or exam, however, is an evaluation of what each individual understands.

Attendance: I will not take attendance during the quarter, but, since we meet only forty-two times during the quarter, it is imperative that you come to each meeting. Please call me (528-4509) or, better, e-mail me (tfurutani@sccd.ctc.edu) if you are going to miss class, so that we can discuss what you have missed.

Dates to remember: Last day to drop course May 27

Last day of instruction June 14

Tentative calendar: the chapter numbers refer to chapters in the Timberlake textbook. This is a provisional calendar and topics/dates are subject to change. The lab topics/ sequence is also subject to change. Check the website for the most up-to-date calendar.

April 4 Intro.

Functional groups

Exercise 1

Chirality, isomers

Biomolecule report

6 No lab

Polarity, solubility

Exercise 2

Redox

Lab 1

Chapter 16: Carbohydrates

Exercise 3